Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity
Identifieur interne : 004159 ( Main/Exploration ); précédent : 004158; suivant : 004160Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity
Auteurs : Cathy Chuang [États-Unis] ; Anne Constantino [États-Unis] ; Casilda Balmaceda [États-Unis] ; David Eidelberg [États-Unis] ; Steven J. Frucht [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-03.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte, Personne âgée.
English descriptors
- KwdEn :
- Adult, Aged, Antineoplastic Agents (adverse effects), Antineoplastic agent, Antiparkinson Agents (therapeutic use), Antiparkinson agent, Case study, Chemotherapy, Elderly, Female, Humans, Levodopa, Levodopa (therapeutic use), Middle Aged, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (drug therapy), Parkinsonism, Polychemotherapy, Toxicity, Treatment, Treatment Outcome, chemotherapy, levodopa, parkinsonism.
- MESH :
- chemical , adverse effects : Antineoplastic Agents.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- chemically induced : Parkinsonian Disorders.
- drug therapy : Parkinsonian Disorders.
- Aged, Female, Humans, Middle Aged, Treatment Outcome.
Abstract
Parkinsonism is a rare neurological complication of cancer treatment. Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10344
Affiliations:
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Le document en format XML
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Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Chuang, Cathy" sort="Chuang, Cathy" uniqKey="Chuang C" first="Cathy" last="Chuang">Cathy Chuang</name></region><name sortKey="Balmaceda, Casilda" sort="Balmaceda, Casilda" uniqKey="Balmaceda C" first="Casilda" last="Balmaceda">Casilda Balmaceda</name><name sortKey="Constantino, Anne" sort="Constantino, Anne" uniqKey="Constantino A" first="Anne" last="Constantino">Anne Constantino</name><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><name sortKey="Frucht, Steven J" sort="Frucht, Steven J" uniqKey="Frucht S" first="Steven J." last="Frucht">Steven J. 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